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Drug Discovery and Development, Drug Discovery



Hardcover: 456 pages
Publisher: Wiley-Interscience (June 16, 2006)
********: English
ISBN: 0471398489
Product Dimensions: 10.1 x 7.3 x 1.1 inches

This two volume set provides a comprehensive account of the entire sequence of operations involved in discovering a drug through the actual delivery of the drug to clinicians and medical practitioners.
Includes case studies of the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil)
Discusses the discovery of agents for the treatment and management of bacterial infections, Parkinson's disease, psoriasis, ulcers and stomach pain, atopic dermatitis, asthma, and cancer
Contains chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics
The first volume of this set thoroughly describes conceptualizing a drug, creating a library of candidates for testing, screening those candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and revising the drug as necessary

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Drug Discovery Handbook



The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs.

This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including:

* Genomics, proteomics, high-throughput screening, and systems biology
* Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more
* Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques

The thorough coverage and practical, scientifically valid problem-solving approach of Drug Discovery Handbook will serve as an invaluable aid in the complex task of developing new drugs.

http://mihd.net/1.678/Drug_Discovery_Handbook.pdf.html

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Principles of Immunopharmacology



Principles of Immunopharmacology
by Frans P. Nijkamp, Michael J. Parnham (Editors)
Paperback: 662 pages
Publisher: Birkhauser; 2 edition (December 22, 2005)
ISBN: 3764358041

Book Description
This textbook provides a unique support in gaining essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The first section of the book, covering a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts. The second section on immunodiagnostics has been further expanded to describe widely used molecular techniques and is followed by a systematic coverage of drugs affecting the immune system, revised to cover recent developments. The book concludes with a chapter on immunotoxicology. This second edition continues the unique format dealing with four related topics in a single volume, obviating the need to refer to several different textbooks. New aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first edition

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Transport Processes in Pharmaceutical Systems



Hardcover: 727 pages
Publisher: CRC; 1st edition (January 15, 2000)
********: English
ISBN-10: 0824766105
ISBN-13: 978-0824766108

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Modified-Release Drug Delivery Technology



Modified-Release Drug Delivery Technology
ISBN: 0824708695
Title: Modified-Release Drug Delivery Technology (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs), 2002-11
Author: Michael J. Rathbone (Editor), Jonathan Hadgraft (Editor), Michael S. Roberts (Editor)
Publisher: Informa Healthcare
Publication Date: 2002-11-07
Number Of Pages: 1032


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Describing formulation challenges and their solutions in the design, development, and commercialization of modified-release drugs delivery systems, this book contains eighty papers that review recent developments in design and manufacturing techniques. It includes detailed descriptions of extended release drug products for the oral, nasal, ophthalmic, pulmonary, vaginal, dermal and transdermal pathways. With the exception of the final section addressing regulatory issues, each section covers a particular route for drug delivery and opens with an overview of the anatomical, physiological, and pharmaceutical basics of each route before moving on to cover specific technologies.


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Biomineralization: Medical Aspects of Solubility



Product Details
»Book Publisher: Wiley (11 September, 2006)
»ISBN: 0470092092
»Book author: Erich Konigsberger, LanChi Konigsberger
»Amazon Rating:

Book Description:
This title takes an interdisciplinary approach to the central role of solubility in pathological biomineralisation, ranging from traditional thermodynamics and kinetics to unusual concepts such as the PILP process. The scientific background and expertise of the contributors, ranges accordingly from solubility modelling and database development, renal stone and bone implant research, Mössbauer spectroscopy and structural chemistry to biochemistry and crystallisation. The chapters all have a quantitative, physico-chemical component rather than giving purely phenomenological descriptions. The contributors deal with aspects and concepts that have not previously been common in the study of pathological biomineralisation processes

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Physiological Pharmaceuticals: Barriers to Drug Absorption



Product Details
»Book Publisher: CRC (15 January, 2001)
»ISBN: 0748405623
»Book author: Neena Washington, Clive Washington, Clive Wilson
»Amazon Rating:

Book Description:
This work provides an integrated approach to the study of drug formulations in the body, with emphasis on formulation variables rather than drugs; reflecting mid-to-late 1990s concentration on new delivery systems rather than new drugs.

http://rapidshare.com/files/4067902/...utics.pdf.html

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Fundamentals of Nuclear Pharmacy



Pages: 383
Publisher: Springer-Verlag, New York
Publication Date: May 18, 2005 (5th edition)
ISBN: 0387403604
Price: 69.95 $
Format: PDF
Size: 8.45 MB (6.40 MB ZIP archive)
********: English

Subject: Radiopharmaceuticals, Nuclear medicine, Pharmacy
Summary:
This is the classic text/reference of nuclear pharmacy, thoroughly updated and judiciously expanded. Generously supplemented with charts, tables, and more than 100 illustrations throughout, each chapter provides the reader with well-delineated descriptions, from the basic autotomic structure through the clinical uses of radiopharmaceuticals. Previous editions were unanimously priased for their clarity and accuracy, as Dr. Saha set new standards for making complex theoretical concepts readily understandable for students and practitioners in nuclear pharmacy and nuclear medicine. New features in the Fourth Edition include: - up-to-date descriptions of the latest NRC and FDA regulations - clinical uses of all new radiopharmaceuticals and techniques, including those radiopharmaceuticals having the potential for clinical use - quality control data for all new radiopharmaceuticals - dosimetry data for all new radiopharmaceuticals - an entire new chapter devoted to the therapeutic uses of radiopharmaceuticals - an upgraded section on 99mTc chemistry - addition to the 62Zn-62Cu generator in th chapter on "Radionuclide Generators" - latest developments in brain, heart, and tumor imaging - a new section on parathyroid imaging From reviuews of the Third Edition: "?the strengths of this edition, coupled with its currentness, make this book today's frontrunner among introductory radiopharmacy texts." -Clinical Nuclear Medicine "?an excellent overview of all different aspects of nuclear pharmacy?consistent, well-written, concise?. I can recommend it as a reference in nuclear pharmacy and as a textbook for nuclear medicine technologists." -European Journal of Nuclear Medicine


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Good Laboratory Practice Regulations, Third Edition, (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs



Book Description:

Fully updated and revised to include the latest information since publication of the first edition in 1989, the Second Edition of this highly praised reference covers all aspects of the Food and Drug Administration’s (FDA) Good Laboratory Practice (GLP) regulations and techniques for implementation. The book details specific standards and general guidelines for the management of efficient and effective research environment. A guide to the current standards and requirements of good laboratory management, the book examines essential theoretical principles for anticipating new and emerging interpretations of GLP in a variety of laboratory settings.

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Drug Targeting: Strategies, Principles, and Applications



G. E. Francis and Cristina Delgado have assembled a comprehensive collection of leading-edge protocols for drug targeting studies. In addition to the detailed step-by-step instruction, the protocols review the principal current targeting strategies, discuss how to build the constructs, examine theoretical considerations relevant to solid tumors, and describe experimental and clinical applications of targeted drug delivery systems. Also present are new chemical and biological approaches to the preparation of targeted biopharmaceuticals, including ribonuclease–antibody chimeras, bispecific antibodies, enzyme–antibody conjugates, and folate-bearing conjugates. Applications include the targeting of myocardial infarctions using liposomal systems, the use of monoclonal antibodies to target malaria and HIV-infected cells, the targeting of fusion proteins to leukemias and lymphomas, and the use of antioxidant enzyme–antibody conjugates to target the pulmonary endothelium. Comprehensive and innovative, Drug Targeting: Strategies, Principles, and Applications documents in practical detail the major new chemical and biological targeting methods now being used to produce today’s emerging rich array of novel diagnostic agents and promising biopharmaceuticals.

1. Chemical Construction of Immunotoxins
Victor Ghetie; Ellen Vitetta
pp. 1-26

2. Construction of Ribonuclease-Antibody Conjugates for Selective Cytotoxicity
Dianne Newton; Susanna Rybak
pp. 27-35

3. Intracellular Targeting Using Bispecific Antibodies
Vic Raso
pp. 37-50

4. Antibody Conjugation Methods for Active Targeting of Liposomes
Steven Ansell; Troy Harasym; Paul Tardi; Susan Buchkowsky; Marcel Bally; Pieter Cullis
pp. 51-68

5. Folate as a Targeting Device for Proteins Utilizing Folate Receptor-Mediated Endocytosis
Robert Lee; Philip Low
pp. 69-76

6. Preparation of Recombinant RNase Single-Chain Antibody Fusion Proteins
Dianne Newton; Susanna Rybak
pp. 77-95

7. Practical Considerations in the Exploitation of Passive Tumor Targeting
Gillian Thomas
pp. 97-113

8. Effect of Dose, Molecular Size, and Binding Affinity on Uptake of Antibodies
Gillian Thomas
pp. 115-132

9. Inhibition of Tumor Blood Flow
Lai-Ming Ching; William Wilson; Bruce Baguley
pp. 133-157

10. Targeting in Myocardial Infarction
Ban Khaw; Vladimir Torchilin
pp. 159-191

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