i waited 4 someone 2 participate in this subject but no use....
anyway i will complete
other anti-bacterial agents..
SULFONAMIDES
Sulfonamides are antibacterial agents, meaning they are active against bacteria. Another term that may be used to describe the general action of these drugs is anti-infective because they are used to treat infections caused by certain bacteria
ACTIONS
The sulfonamides are primarily bacteriostatic, which means they slow or retard the multiplication of bacteria. This bacteriostatic activity is due to sulfonamide antagonism to para-aminobenzoic acid (PABA), a substance that some, but not all, bacteria need to multiply. Once the rate of bacterial multiplication is slowed, the body’s own defense mechanisms (white blood cells) are able to rid the body of the invading microorganisms and therefore control the infection.
USES
1- urinary tract infections "caused by Escherichia coli,Staphylococcus aureus, and Klebsiella-Enterobacter.
2- treat chancroid and acute otitis media
3- sulfasalazine used in rheumatoid arthritis
4- mafenide and silver sulfadiazine used in the treatment of second- and third-degree burns
ADVERSE REACTIONS
1- Agranulocytosis—decrease in or lack of granulocytes, a type of white blood cell
2- Thrombocytopenia—decrease in the number of platelets
3- Aplastic anemia—anemia due to deficient red blood cell production in the bone marrow
4- Leukopenia—decrease in the number of white blood cells
5- other side effects like anorexia, pruritus, stomatitis and crystalluria "crystals in urine"
CONTRAINDICATIONS
1- during lactation
2- children less than 2 years old
3- pregnancy "Pregnancy Category C" so If the sulfonamides are given near the end of pregnancy, significant blood levels of the drug may occur, causing jaundice or hemolytic anemia in the neonate
PRECAUTIONS
patients with renal and hepatic failure
INTERACTIONS
1- increase the action of anti-coagulant
2- The risk of bone marrow suppression may be increased when a sulfonamide is administered with methotrexate.
EXAMPLES
sutrim, septazole